2. Academic Validation
  3. Structure-activity relationship studies of flavopiridol analogues

Structure-activity relationship studies of flavopiridol analogues

  • Bioorg Med Chem Lett. 2000 May 15;10(10):1037-41. doi: 10.1016/s0960-894x(00)00156-6.
K K Murthi 1,  M Dubay,  C McClure,  L Brizuela,  M D Boisclair,  P J Worland,  M M Mansuri,  K Pal
Affiliations

Affiliation

  • 1 Department of Medicinal Chemistry, Mitotix Inc., Cambridge, MA 02139, USA. [email protected]
PMID: 10843211 DOI: 10.1016/s0960-894x(00)00156-6
Abstract

Cyclin dependent kinases (CDKs) along with the complementary cyclins form key regulatory checkpoint controls on the cell cycle. Flavopiridol is a synthetic flavone that shows potent and selective cyclin-dependent kinase inhibitory activity. In this paper, we report modifications of the 3-hydroxy-1-methylpiperidinyl (D ring) of flavopiridol and their effect on CDK inhibitory activity.

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