2. Academic Validation
  3. Synthesis and cytotoxic activity of acetogenin analogues

Synthesis and cytotoxic activity of acetogenin analogues

  • Bioorg Med Chem Lett. 2000 Jun 19;10(12):1373-5. doi: 10.1016/s0960-894x(00)00236-5.
S Rodier 1,  Y Le Huérou,  B Renoux,  J Doyon,  P Renard,  A Pierré,  J P Gesson,  R Grée
Affiliations

Affiliation

  • 1 Laboratoire de Synthèse et Réactivité des Substances Naturelles, Université de Poitiers et CNRS, France.
PMID: 10890167 DOI: 10.1016/s0960-894x(00)00236-5
Abstract

A set of 16 new simplified analogues of acetogenins has been designed based on: (i) the replacement of the bis THF moiety of these natural products by an ethylene glycol bis ether unit; (ii) the introduction of different lipophilic side chains (alkyl, aryl, dialkylamino, O-cholesteryl); (iii) the presence of the same terminal isolactone. In vitro cytotoxic activity against L1210 leukemia is reported.

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