2. Academic Validation
  3. Synthesis of ecteinascidin ET-743 and phthalascidin Pt-650 from cyanosafracin B

Synthesis of ecteinascidin ET-743 and phthalascidin Pt-650 from cyanosafracin B

  • Org Lett. 2000 Aug 10;2(16):2545-8. doi: 10.1021/ol0062502.
C Cuevas 1,  M Pérez,  M J Martín,  J L Chicharro,  C Fernández-Rivas,  M Flores,  A Francesch,  P Gallego,  M Zarzuelo,  F de La Calle,  J García,  C Polanco,  I Rodríguez,  I Manzanares
Affiliations

Affiliation

  • 1 Pharma Mar, S. A. C/ de la Calera 3, 28760-Tres Cantos, Madrid, Spain.
PMID: 10956543 DOI: 10.1021/ol0062502
Abstract

An efficient new process is described for the synthesis of ecteinascidin ET-743 (1) and phthalascidin (2), starting from readily available cyanosafracin B (3).

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