2. Academic Validation
  3. Structure-activity relationship of polyisoprenyl benzophenones from Garcinia pyrifera on the tubulin/microtubule system

Structure-activity relationship of polyisoprenyl benzophenones from Garcinia pyrifera on the tubulin/microtubule system

  • J Nat Prod. 2000 Aug;63(8):1070-6. doi: 10.1021/np0000872.
D Roux 1,  H A Hadi,  S Thoret,  D Guénard,  O Thoison,  M Païs,  T Sévenet
Affiliations

Affiliation

  • 1 Institut de Chimie des Substances Naturelles, Centre National de la Recherche Scientifique, 91198 Gif-sur-Yvette Cedex, France.
PMID: 10978200 DOI: 10.1021/np0000872
Abstract

Microtubule disassembly inhibitory properties have been established for the known polyisoprenylated benzophenones xanthochymol (1a) and guttiferone E (1b). The compounds were isolated from the fruits of Garcinia pyrifera collected in Malaysia. A structure-activity relationship study, including natural and semisynthetic derivatives, delineated some structural features necessary for the interaction with tubulin within this compound class.

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