2. Academic Validation
  3. Synthesis of metabolically blocked paclitaxel analogues

Synthesis of metabolically blocked paclitaxel analogues

  • Bioorg Med Chem Lett. 2001 Mar 26;11(6):809-10. doi: 10.1016/s0960-894x(01)00066-x.
M D Wittman 1,  T J Altstadt,  C Fairchild,  S Hansel,  K Johnston,  J F Kadow,  B H Long,  W C Rose,  D M Vyas,  M J Wu,  M E Zoeckler
Affiliations

Affiliation

  • 1 Discovery Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, CT 06492-7660, USA. [email protected]
PMID: 11277525 DOI: 10.1016/s0960-894x(01)00066-x
Abstract

The stereospecific syntheses of the metabolically blocked 6-alpha-F, Cl, Br paclitaxel, and 6-alpha-F-10-acetyldocetaxel are described and in vitro and in vivo activity is presented.

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