2. Academic Validation
  3. Synthesis and antitumor activity of novel paclitaxel-chlorambucil hybrids

Synthesis and antitumor activity of novel paclitaxel-chlorambucil hybrids

  • Bioorg Med Chem Lett. 2001 Mar 26;11(6):811-4. doi: 10.1016/s0960-894x(01)00067-1.
M D Wittman 1,  J F Kadow,  D M Vyas,  F L Lee,  W C Rose,  B H Long,  C Fairchild,  K Johnston
Affiliations

Affiliation

  • 1 Discovery Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, CT 06492-7660, USA. [email protected]
PMID: 11277526 DOI: 10.1016/s0960-894x(01)00067-1
Abstract

The syntheses and antitumor activity of three paclitaxel-chlorambucil hybrids are presented. Hybrid 3 showed significant in vivo efficacy.

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