2. Academic Validation
  3. Structure-activity relationships of phenylcyclohexene and biphenyl antitubulin compounds against plant and mammalian cells

Structure-activity relationships of phenylcyclohexene and biphenyl antitubulin compounds against plant and mammalian cells

  • Bioorg Med Chem Lett. 2001 Jun 4;11(11):1393-6. doi: 10.1016/s0960-894x(01)00246-3.
D H Young 1,  C M Tice,  E L Michelotti,  R C Roemmele,  R A Slawecki,  F M Rubio,  J A Rolling
Affiliations

Affiliation

  • 1 Rohm and Haas Company, 727Norristown Road, Spring House, PA 19477-0904, USA. [email protected]
PMID: 11378362 DOI: 10.1016/s0960-894x(01)00246-3
Abstract

Phenylcyclohexenes (PCHs) [e.g., trans-4-nitro-5-(2,3,4-trimethoxyphenyl)cyclohexene, 2d] were found to bind weakly to the colchicine site of bovine tubulin, but are the first mimics of colchicine found to have high activity towards plant cells. Structure-activity relationships for PCHs and biphenyl AC-ring analogues of colchicine (e.g., 2,3,4,4'-tetramethoxy-2'-methyl-1,1'-biphenyl, 3e) are discussed.

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