2. Academic Validation
  3. Chemical constituents from Lippia sidoides and cytotoxic activity

Chemical constituents from Lippia sidoides and cytotoxic activity

  • J Nat Prod. 2001 Jun;64(6):792-5. doi: 10.1021/np0005917.
S M Costa 1,  T L Lemos,  O D Pessoa,  C Pessoa,  R C Montenegro,  R Braz-Filho
Affiliations

Affiliation

  • 1 Departamento de Química Orgânica e Inorgânica, Universidade Vale do Acaraú, CP 12200 60451-970 Fortaleza, Ceará, Brazil.
PMID: 11421746 DOI: 10.1021/np0005917
Abstract

Eleven known compounds and a new prenylated naphthoquinone, lippsidoquinone (13), were isolated from ethanol extracts of Lippia sidoides. Their structures were established by a combination of 1D and 2D NMR, IR, and EIMS spectral data analysis. The cytotoxic properties of compounds 3--13 were evaluated against HL60, SW1573, and CEM cell lines. Only tectol (6) and lippsidoquinone (13) exhibited significant activity against human leukemia cell lines HL60 and CEM.

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