2. Academic Validation
  3. Enantioselective synthesis and complement inhibitory assay of A/B-ring partial analogues of oleanolic acid

Enantioselective synthesis and complement inhibitory assay of A/B-ring partial analogues of oleanolic acid

  • Bioorg Med Chem Lett. 2001 Jul 9;11(13):1619-23. doi: 10.1016/s0960-894x(01)00210-4.
H Assefa 1,  A Nimrod,  L Walker,  R Sindelar
Affiliations

Affiliation

  • 1 Department of Medicinal Chemistry, School of Pharmacy, University of Mississippi, University, MS 38677, USA.
PMID: 11425522 DOI: 10.1016/s0960-894x(01)00210-4
Abstract

A series of oleanolic acid A/B-ring partial analogues was synthesized and tested for their complement inhibitory activity as well as cytotoxic properties. All target compounds and one intermediate exhibited moderate complement inhibitory potency. These compounds also showed cytotoxicity on malignant melanoma cell line, SK-MEL.

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