2. Academic Validation
  3. Antimycobacterial activity of 9-sulfonylated/sulfenylated-6-mercaptopurine derivatives

Antimycobacterial activity of 9-sulfonylated/sulfenylated-6-mercaptopurine derivatives

  • Bioorg Med Chem Lett. 2001 Jul 9;11(13):1675-8. doi: 10.1016/s0960-894x(01)00266-9.
A Scozzafava 1,  A Mastrolorenzo,  C T Supuran
Affiliations

Affiliation

  • 1 Laboratorio di Chimica Inorganica e Bioinorganica, Università degli Studi, Via Gino Capponi 7, I-50121, Florence, Italy.
PMID: 11425535 DOI: 10.1016/s0960-894x(01)00266-9
Abstract

A series of 9-sulfonylated/sulfenylated-6-mercaptopurines has been prepared by reaction of 6-mercaptopurine with sulfonyl/sulfenyl halides. These compounds constitute a new class of potent antimycobacterial agents, possessing MIC values against Mycobacterium tuberculosis H37Rv in the range of 0.39-3.39 microg/mL, as well as appreciable activity against Mycobacterium avium. Furthermore, a compound of this small series exhibited good activity (MIC under 1 microg/mL) against several drug resistant strains of M. tuberculosis.

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