2. Academic Validation
  3. Phenylcyanoguanidines as inhibitors of glucose-induced insulin secretion from beta cells

Phenylcyanoguanidines as inhibitors of glucose-induced insulin secretion from beta cells

  • Bioorg Med Chem Lett. 2001 Jul 9;11(13):1749-52. doi: 10.1016/s0960-894x(01)00297-9.
T M Tagmose 1,  J P Mogensen,  P C Agerholm,  P O Arkhammar,  P Wahl,  A Worsaae,  J B Hansen
Affiliations

Affiliation

  • 1 Discovery and Development, Novo Nordisk A/S, Novo Nordisk Park, DK-2760, Måløv, Denmark.
PMID: 11425552 DOI: 10.1016/s0960-894x(01)00297-9
Abstract

3,5-Disubstituted-phenylcyanoguanidines have been identified as activators of SUR1/Kir6.2 potassium channels and as potent inhibitors of Insulin release from pancreatic beta cells in vitro.

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