2. Academic Validation
  3. Synthesis of N-alkyl substituted indolocarbazoles as potent inhibitors of human cytomegalovirus replication

Synthesis of N-alkyl substituted indolocarbazoles as potent inhibitors of human cytomegalovirus replication

  • Bioorg Med Chem Lett. 2001 Aug 6;11(15):1993-5. doi: 10.1016/s0960-894x(01)00352-3.
M J Slater 1,  R Baxter,  R W Bonser,  S Cockerill,  K Gohil,  N Parry,  E Robinson,  R Randall,  C Yeates,  W Snowden,  A Walters
Affiliations

Affiliation

  • 1 GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, SG1 2NY, Stevenage, UK. [email protected]
PMID: 11454465 DOI: 10.1016/s0960-894x(01)00352-3
Abstract

The synthesis and Antiviral evaluation of unsymmetrical indolocarbazole derivatives of Arcyriaflavin A, substituted with a range of alkyl groups at the indole nitrogen, is described. Structure-activity relationships in this series against human cytomegalovirus (HCMV) replication in Cell Culture are reported. Compound 4b was identified as potent inhibitor of HCMV (IC(50)=19 nM), which retained activity against a range of HCMV strains including ganciclovir resistant isolates.

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