2. Academic Validation
  3. Photochemical synthesis of N-arylbenzophenanthridine selective estrogen receptor modulators (serms)

Photochemical synthesis of N-arylbenzophenanthridine selective estrogen receptor modulators (serms)

  • J Med Chem. 2001 Aug 16;44(17):2857-60. doi: 10.1021/jm0101601.
T A Grese 1,  M D Adrian,  D L Phillips,  P K Shetler,  L L Short,  A L Glasebrook,  H U Bryant
Affiliations

Affiliation

  • 1 Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA. [email protected]
PMID: 11495597 DOI: 10.1021/jm0101601
Abstract

Selective Estrogen receptor modulators are an emerging class of pharmaceutically important molecules. Many compounds in this class contain an aminoethoxyaryl moiety attached to a polycyclic framework at an asymmetric carbon atom. To assess whether this carbon atom can be replaced by nitrogen, we have employed a Ninomiya enamide photocyclization for the rapid synthesis of a novel N-arylbenzophenanthridine framework, 4. Further elaboration of 4 into a new structural class of achiral, nonsteroidal Estrogen receptor modulators is described.

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