2. Academic Validation
  3. Anticancer properties for 4,4'-dihydroxybenzophenone-2,4-dinitrophenylhydrazone (A-007)/3,7-diaminophenothiazin-5-ium double salts

Anticancer properties for 4,4'-dihydroxybenzophenone-2,4-dinitrophenylhydrazone (A-007)/3,7-diaminophenothiazin-5-ium double salts

  • Bioorg Med Chem Lett. 2001 Aug 20;11(16):2193-5. doi: 10.1016/s0960-894x(01)00408-5.
L R Morgan 1,  A H Rodgers,  B W LeBlanc,  S M Boué,  Y Yang,  B S Jursic,  R B Cole
Affiliations

Affiliation

PMID: 11514168 DOI: 10.1016/s0960-894x(01)00408-5
Abstract

4,4'-Dihydroxybenzophenone-2,4-dinitrophenylhydrazone (A-007) formed stable double salts with phenothiazin-5-ium salts (2a-d), which have improved in vitro Anticancer activities, as compared to A-007 alone. The stable salt between methylene blue (2a) and A-007 allowed the latter to diffuse into the dermis layers of skin. It is anticipated that these new salts will allow A-007 to penetrate into the deep lymphatic/vascular channels of the dermis, which contain metastatic Cancer cells, and improve in vivo Anticancer activities.

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