2. Academic Validation
  3. Cytotoxic diacetylenes from the stony coral Montipora species

Cytotoxic diacetylenes from the stony coral Montipora species

  • J Nat Prod. 2001 Aug;64(8):1059-63. doi: 10.1021/np010148b.
N Alam 1,  B H Bae,  J Hong,  C O Lee,  K S Im,  J H Jung
Affiliations

Affiliation

  • 1 College of Pharmacy, Pusan National University, Pusan 609-735, Korea.
PMID: 11520227 DOI: 10.1021/np010148b
Abstract

Ten new (1, 4-6, 9-14) and four known (2, 3, 7, 8) diacetylenes have been isolated from a brine shrimp active fraction of the methanolic extract of the stony coral Montipora sp. The structures were determined by combined spectroscopic methods. The compounds exhibited significant cytotoxicity against a small panel of human solid tumor cell lines. Montiporyne A (15), a previously reported congener, was also found to induce Apoptosis in human colon tumor cell.

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