2. Academic Validation
  3. New inhibitors of the thioredoxin-thioredoxin reductase system based on a naphthoquinone spiroketal natural product lead

New inhibitors of the thioredoxin-thioredoxin reductase system based on a naphthoquinone spiroketal natural product lead

  • Bioorg Med Chem Lett. 2001 Oct 8;11(19):2637-41. doi: 10.1016/s0960-894x(01)00525-x.
P Wipf 1,  T D Hopkins,  J K Jung,  S Rodriguez,  A Birmingham,  E C Southwick,  J S Lazo,  G Powis
Affiliations

Affiliation

  • 1 Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA. [email protected]
PMID: 11551767 DOI: 10.1016/s0960-894x(01)00525-x
Abstract

Natural products of the naphthoquinone spiroketal structural type served as lead structures for the development of novel inhibitors of the thioredoxin-thioredoxin reductase redox system. The most potent compound in this series inhibited thioredoxin with an IC(50) of 350 nM, and many derivatives showed low micromolar activities for growth inhibition against two breast Cancer cell lines.

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