2. Academic Validation
  3. Synthesis and cytotoxicity on sensitive and doxorubicin-resistant cell lines of new pyrrolo[2,1-c][1,4]benzodiazepines related to anthramycin

Synthesis and cytotoxicity on sensitive and doxorubicin-resistant cell lines of new pyrrolo[2,1-c][1,4]benzodiazepines related to anthramycin

  • J Med Chem. 2001 Oct 25;44(22):3754-7. doi: 10.1021/jm010937q.
N Langlois 1,  A Rojas-Rousseau,  C Gaspard,  G H Werner,  F Darro,  R Kiss
Affiliations

Affiliation

  • 1 Institut de Chimie des Substances Naturelles, CNRS, 91198 Gif-sur-Yvette, France. [email protected]
PMID: 11606141 DOI: 10.1021/jm010937q
Abstract

A new 7,8-methylenedioxy analogue (4) of (+)-porothramycin B (2) and its water-soluble sodium bisulfite derivative (15) have been synthesized in high yields and have been shown to exhibit high cytotoxic activities against several tumor cell lines. The new pyrrolo[2,1-c][1,4]benzodiazepine 4 was as effective against the resistant cell lines as against the doxorubicin-sensitive cell lines tested.

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