2. Academic Validation
  3. New cytotoxic sesterterpenes from the sponge Sarcotragus species

New cytotoxic sesterterpenes from the sponge Sarcotragus species

  • J Nat Prod. 2001 Oct;64(10):1301-4. doi: 10.1021/np0101494.
Y Liu 1,  B H Bae,  N Alam,  J Hong,  C J Sim,  C O Lee,  K S Im,  J H Jung
Affiliations

Affiliation

  • 1 College of Pharmacy, Pusan National University, Pusan 609-735, Korea.
PMID: 11678655 DOI: 10.1021/np0101494
Abstract

Five new (1-3, 5, and 7) and two known (4, 6) furanosesterterpene tetronic acids were isolated from the marine Sponge Sarcotragus sp. by bioactivity-guided fractionation. These compounds showed cytotoxicity against a panel of five human tumor cell lines. The gross structures were established on the basis of NMR and MS analyses. The compounds showed interesting variations of geometry and absolute configuration.

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