2. Academic Validation
  3. HBP2: a new mammalian protein that complements the fission yeast MBF transcription complex

HBP2: a new mammalian protein that complements the fission yeast MBF transcription complex

  • Curr Genet. 2001 Sep;40(2):110-8. doi: 10.1007/s002940100241.
A Sánchez-Díaz 1,  M A Blanco,  N Jones,  S Moreno
Affiliations

Affiliation

  • 1 Instituto de Microbiologia Bioquimica, Departamento de Microbiologia y Genética, CSIC/Universidad de Salamanca, Spain.
PMID: 11680820 DOI: 10.1007/s002940100241
Abstract

The mammalian HBP2 gene has been isolated by functional complementation of cells unable to undergo DNA replication in fission yeast. HBP2 is a protein with a high mobility group (HMG) domain that belongs to the Sox (Sry-related HMG box) family of transcription factors. As in other members of the family, the HMG box in HBP2 is a DNA-binding domain that is essential for its function in Schizosaccharomyces pombe. Expression of HBP2 in fission yeast activates CdclO-dependent transcription at G1/S and allows growth of cdc10-129, resldelta and rep2delta mutant cells at the restrictive temperature. The mammalian HBP2 activates transcription at G1/S in the fission yeast Sch. pombe.

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