2. Academic Validation
  3. Combretoxazolones: synthesis, cytotoxicity and antitumor activity

Combretoxazolones: synthesis, cytotoxicity and antitumor activity

  • Bioorg Med Chem Lett. 2001 Dec 3;11(23):3073-6. doi: 10.1016/s0960-894x(01)00622-9.
N H Nam 1,  Y Kim,  Y J You,  D H Hong,  H M Kim,  B Z Ahn
Affiliations

Affiliation

  • 1 College of Pharmacy, Chungnam National University, Taejon 305-764, Republic of Korea.
PMID: 11714613 DOI: 10.1016/s0960-894x(01)00622-9
Abstract

Two series of combretoxazolones including 3,4-diaryloxazolones (6) and 4,5-diaryloxazolones (7) were synthesized and evaluated for cytotoxicity and antitumor activity. Both series showed strong cytotoxicities against a variety of tumor cell lines. Compound 6g exhibited a significant antitumor activity in BDF1 mice bearing B16 murine melanoma cells with inhibition rates of 67 and 61% at 100 and 30 mg/kg/day, respectively.

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