Macharistol, a new cytotoxic cinnamylphenol from the stems of Machaerium aristulatum

J Nat Prod. 2001 Nov;64(11):1483-5. doi: 10.1021/np0103158.

E K Seo ¹, N C Kim, Q Mi, H Chai, M E Wall, M C Wani, H A Navarro, J P Burgess, J G Graham, F Cabieses, G T Tan, N R Farnsworth, J M Pezzuto, A D Kinghorn

Affiliations

Affiliation

1 Chemistry and Life Sciences, Research Triangle Institute, P.O. Box 12194, Research Triangle Park, North Carolina 27709, USA.

PMID: 11720542 DOI: 10.1021/np0103158

Abstract

A new cinnamylphenol, macharistol (1), along with a known pterocarpan, (+)-medicarpin (2), were isolated as cytotoxic constituents from the stems of Machaerium aristulatum. In addition, a known pterocarpan, (+)-maackiain (3), and a known isoflavone, formononetin (4), were identified as inactive constituents. Compound 1 was evaluated in the in vivo hollow fiber assay with KB, Col-2, and hTERT-RPE1 cells and found to be inactive at the highest dose (25 mg/kg body weight) tested.

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