2. Academic Validation
  3. Synthesis and anti-HIV activity of oleanolic acid derivatives

Synthesis and anti-HIV activity of oleanolic acid derivatives

  • Bioorg Med Chem Lett. 2001 Dec 17;11(24):3115-8. doi: 10.1016/s0960-894x(01)00647-3.
Y M Zhu 1,  J K Shen,  H K Wang,  L M Cosentino,  K H Lee
Affiliations

Affiliation

  • 1 Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 294 Taiyuan Road, 200031, Shanghai, China.
PMID: 11720855 DOI: 10.1016/s0960-894x(01)00647-3
Abstract

Thirteen oleanolic acid derivatives were prepared and evaluated for anti-HIV activity in H9 lymphocytes. Saturating the C(12)-C(13) double bond and converting the C(17)-carboxyl group to an aminomethyl group led to compounds 13-15 and 19-20, respectively, which showed improved anti-HIV activity. Compound 15 was the most potent derivative with EC(50)=0.0039 microg/mL and TI=3570.

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