2. Academic Validation
  3. Synthesis and antiproliferative activity of some thiazolylbenzimidazole-4,7-diones

Synthesis and antiproliferative activity of some thiazolylbenzimidazole-4,7-diones

  • Bioorg Med Chem Lett. 2001 Dec 17;11(24):3147-9. doi: 10.1016/s0960-894x(01)00639-4.
L Garuti 1,  M Roberti,  A Pession,  E Leoncini,  S Hrelia
Affiliations

Affiliation

  • 1 Department of Pharmaceutical Science, University of Bologna, via Belmeloro 6, I-40126, Bologna, Italy. [email protected]
PMID: 11720862 DOI: 10.1016/s0960-894x(01)00639-4
Abstract

Some thiazolylbenzimidazole-4,7-diones were synthesized and tested in vitro on two tumor cell lines. Compounds 2d and 2e show a very good activity on K562 cells, whereas compounds 2a and 2b are active on SW620 cells. The importance of the methoxy group on the quinone moiety is confirmed and the function at 4-position of the thiazole ring plays a determining role for the activity.

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