2. Academic Validation
  3. Design, synthesis and evaluation of substituted phenylpropanoic acid derivatives as peroxisome proliferator-activated receptor (PPAR) activators: novel human PPARalpha-selective activators

Design, synthesis and evaluation of substituted phenylpropanoic acid derivatives as peroxisome proliferator-activated receptor (PPAR) activators: novel human PPARalpha-selective activators

  • Bioorg Med Chem Lett. 2002 Jan 7;12(1):77-80. doi: 10.1016/s0960-894x(01)00672-2.
Hiroyuki Miyachi 1,  Masahiro Nomura,  Takahiro Tanase,  Yukie Takahashi,  Tomohiro Ide,  Masaki Tsunoda,  Koji Murakami,  Katsuya Awano
Affiliations

Affiliation

  • 1 Discovery Research Laboratories, Kyorin Pharmaceutical Co., Ltd., 2399-1Mitarai, Nogi-machi, Shimotsuga-gun, 329-0114, Tochigi, Japan. [email protected]
PMID: 11738577 DOI: 10.1016/s0960-894x(01)00672-2
Abstract

A series of substituted phenylpropanoic acid derivatives was prepared as part of a search for subtype-selective human Peroxisome Proliferator-activated Receptor (PPAR) activators. Structure-activity relationship studies indicated that the substituent at the alpha-position of the carboxyl group plays a key role in determining the potency and the selectivity for PPAR transactivation.

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