2. Academic Validation
  3. A new antibiotic CJ-17,665 from Aspergillus ochraceus

A new antibiotic CJ-17,665 from Aspergillus ochraceus

  • J Antibiot (Tokyo). 2001 Nov;54(11):911-6. doi: 10.7164/antibiotics.54.911.
Y Sugie 1,  H Hirai,  T Inagaki,  M Ishiguro,  Y J Kim,  Y Kojima,  T Sakakibara,  S Sakemi,  A Sugiura,  Y Suzuki,  L Brennan,  J Duignan,  L H Huang,  J Sutcliffe,  N Kojima
Affiliations

Affiliation

  • 1 Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc., Aichi, Japan. [email protected]
PMID: 11827033 DOI: 10.7164/antibiotics.54.911
Abstract

A new Antibiotic, CJ-17,665 (I) was isolated from the fermentation broth of Aspergillus ochraceus, CL41582. It inhibits growth of multi-drug resistant Staphylococcus aureus, Streptococcus pyogenes, and Enterococcus faecalis, with MICs of 12.5, 12.5 and 25 microg/ml, respectively. The structure contains a diketopiperazine and an indole N-oxide moiety that is unusual in Natural Products.

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