2. Academic Validation
  3. Synthesis and notable antimalarial activity of acyclic peroxides, L-(alkyldioxy)-L-(methyldioxy)cyclododecanes

Synthesis and notable antimalarial activity of acyclic peroxides, L-(alkyldioxy)-L-(methyldioxy)cyclododecanes

  • J Med Chem. 2002 Mar 14;45(6):1374-8. doi: 10.1021/jm010473w.
Yoshiaki Hamada 1,  Hidekazu Tokuhara,  Araki Masuyama,  Masatomo Nojima,  Hye-Sook Kim,  Kanako Ono,  Naoki Ogura,  Yusuke Wataya
Affiliations

Affiliation

  • 1 Department of Materials Chemistry & Frontier Research Center, Graduate School of Engineering, Osaka University, Suita, Osaka 565-0871, Japan.
PMID: 11882006 DOI: 10.1021/jm010473w
Abstract

Of several bis(alkyldioxy)alkanes and the related acyclic peroxides prepared in this study, 1,1-bis(methyldioxy)cyclododecane showed the most notable antimalarial activity particularly in vivo (almost a half of that of artemisinin).

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