2. Academic Validation
  3. Isolation, structure elucidation, and absolute configuration of 26-deoxyactein from Cimicifuga racemosa and clarification of nomenclature associated with 27-deoxyactein

Isolation, structure elucidation, and absolute configuration of 26-deoxyactein from Cimicifuga racemosa and clarification of nomenclature associated with 27-deoxyactein

  • J Nat Prod. 2002 Apr;65(4):601-5. doi: 10.1021/np010494t.
Shao-Nong Chen 1,  Wenkui Li,  Daniel S Fabricant,  Bernard D Santarsiero,  Andrew Mesecar,  John F Fitzloff,  Harry H S Fong,  Norman R Farnsworth
Affiliations

Affiliation

  • 1 Program for Collaborative Research in the Pharmaceutical Sciences (PCRPS, M/C 877), Department of Medicinal Chemistry, College of Pharmacy, University of Illinois at Chicago, 60612, USA.
PMID: 11975513 DOI: 10.1021/np010494t
Abstract

A new triterpene glycoside, 26-deoxyactein (1), along with two known compounds, 23-epi-26-deoxyactein (2), previously designated as "27-deoxyactein", and actein (3), were isolated from the roots/rhizomes of Cimicifuga racemosa. The structures and absolute stereochemistry of 1 and 2 were established by spectroscopic methods (FABMS, (1)H and (13)C NMR) and single-crystal X-ray data analysis.

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