2. Academic Validation
  3. Design and synthesis of some new pyranoxanthenone aminoderivatives with cytotoxic activity

Design and synthesis of some new pyranoxanthenone aminoderivatives with cytotoxic activity

  • Bioorg Med Chem Lett. 2002 Jun 3;12(11):1443-6. doi: 10.1016/s0960-894x(02)00218-4.
George Kolokythas 1,  Ioannis K Kostakis,  Nicole Pouli,  Panagiotis Marakos,  Alexios-Leandros Skaltsounis,  Harris Pratsinis
Affiliations

Affiliation

  • 1 Division of Pharmaceutical Chemistry, Department of Pharmacy, University of Athens, Panepistimiopolis-Zografou, 15771, Greece.
PMID: 12031316 DOI: 10.1016/s0960-894x(02)00218-4
Abstract

The synthesis, DNA binding and in vitro cytotoxicity of a series of novel pyranoxanthones, analogues of the acridone alcaloid acronycine, are described. The new compounds proved to bind weakly to DNA. On the contrary, they exhibited interesting cytotoxic activity against murine leukemia L1210 cell line, as well as against some human solid tumor cell lines.

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