2. Academic Validation
  3. 8-Methoxyquinoline-5-carboxamides as PDE4 inhibitors: a potential treatment for asthma

8-Methoxyquinoline-5-carboxamides as PDE4 inhibitors: a potential treatment for asthma

  • Bioorg Med Chem Lett. 2002 Jun 17;12(12):1613-5. doi: 10.1016/s0960-894x(02)00223-8.
George M Buckley 1,  Nicola Cooper,  Hazel J Dyke,  Fiona P Galleway,  Lewis Gowers,  Alan F Haughan,  Hannah J Kendall,  Christopher Lowe,  Robert Maxey,  John G Montana,  Robert Naylor,  Janet Oxford,  Joanna C Peake,  C Louise Picken,  Karen A Runcie,  Verity Sabin,  Andrew Sharpe,  Julie B H Warneck
Affiliations

Affiliation

  • 1 Celltech R&D, Granta Park, Great Abington, Cambridge CB1 6GS, UK.
PMID: 12039574 DOI: 10.1016/s0960-894x(02)00223-8
Abstract

A series of bicyclic heteroaryl ring systems was considered as a replacement for the 3-cyclopentyloxy-4-methoxyphenyl moiety in rolipram resulting in the discovery of 8-methoxyquinoline-5-carboxamides as potent inhibitors of phosphodiesterase type 4 (PDE4).

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