2. Academic Validation
  3. Somatic glypican 3 (GPC3) mutations in Wilms' tumour

Somatic glypican 3 (GPC3) mutations in Wilms' tumour

  • Br J Cancer. 2002 Jun 17;86(12):1920-2. doi: 10.1038/sj.bjc.6600417.
G R M White 1,  A M Kelsey,  J M Varley,  J M Birch
Affiliations

Affiliation

  • 1 Cancer Research UK Cancer Genetics Group, Paterson Institute for Cancer Research, Wilmslow Road, Manchester M20 4BX, UK.
PMID: 12085187 DOI: 10.1038/sj.bjc.6600417
Abstract

Tumour and normal tissue from 41 male cases of Wilms' tumour were screened to determine the presence of sequence variants in the glypican 3 (GPC3) gene. Two non-conservative single base changes were present in tumour tissue only. These findings imply a possible role for GPC3 in Wilms' tumour development.

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