2. Academic Validation
  3. Hydrazinocurcumin, a novel synthetic curcumin derivative, is a potent inhibitor of endothelial cell proliferation

Hydrazinocurcumin, a novel synthetic curcumin derivative, is a potent inhibitor of endothelial cell proliferation

  • Bioorg Med Chem. 2002 Sep;10(9):2987-92. doi: 10.1016/s0968-0896(02)00129-3.
Joong Sup Shim 1,  Dong Hoon Kim,  Hye Jin Jung,  Jin Hee Kim,  Dongyeol Lim,  Seok-Ki Lee,  Kyu-Won Kim,  Jong Woong Ahn,  Jong-Shin Yoo,  Jung-Rae Rho,  Jongheon Shin,  Ho Jeong Kwon
Affiliations

Affiliation

  • 1 Department of Bioscience and Biotechnology, Institute of Bioscience, Sejong University, 98 Kunja-dong, Kwangjin-gu, 143-747, Seoul, South Korea
PMID: 12110321 DOI: 10.1016/s0968-0896(02)00129-3
Abstract

Curcumin and some of its derivatives were known as in vivo inhibitors of angiogenesis. In present study, a novel curcumin derivative, named hydrazinocurcumin (HC) was synthesized and examined for its biological activities. HC potently inhibited the proliferation of bovine aortic endothelial cells (BAECs) at a nanomolar concentration (IC(50)=520 nM) without cytotoxicity. In vivo and in vitro angiogenesis experiments showed HC as a new candidate for anti-angiogenic agent.

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