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  4. Hydrazinocurcumin

Hydrazinocurcumin (Curcumin pyrazole) is a potent endothelial cell proliferation inhibitor (IC50=520 nM). Hydrazinocurcumin disrupts angiogenic signaling pathways and inhibits endothelial cell migration and tube formation, exerting anti-angiogenic activity. Hydrazinocurcumin is promising for research of tumor angiogenesis inhibition, metastatic cancer, and vascular-dependent diseases such as retinopathies.

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Hydrazinocurcumin

Hydrazinocurcumin Chemical Structure

CAS No. : 131068-23-0

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Hydrazinocurcumin Related Antibodies

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Description

Hydrazinocurcumin (Curcumin pyrazole) is a potent endothelial cell proliferation inhibitor (IC50=520 nM). Hydrazinocurcumin disrupts angiogenic signaling pathways and inhibits endothelial cell migration and tube formation, exerting anti-angiogenic activity. Hydrazinocurcumin is promising for research of tumor angiogenesis inhibition, metastatic cancer, and vascular-dependent diseases such as retinopathies[1].

Cellular Effect
Cell Line Type Value Description References
Caco-2 IC50
19.4 μM
Compound: 1
Reduction of MMP9 activity in TNF-alpha/IL1-beta-stimulated human Caco-2 cells treated 1 hr before stimulation by zymography
Reduction of MMP9 activity in TNF-alpha/IL1-beta-stimulated human Caco-2 cells treated 1 hr before stimulation by zymography
[PMID: 19128977]
Ehrlich ED50
100 mM
Compound: 10
Cytotoxicity against Mus musculus (mouse) EAC assessed as cell viability by trypan blue exclusion assay
Cytotoxicity against Mus musculus (mouse) EAC assessed as cell viability by trypan blue exclusion assay
10.1007/s00044-009-9199-3
HaCaT IC50
16.2 μM
Compound: 5
Inhibition of STAT3 transcriptional activity in human HaCaT cells after 6 hrs by luciferase reporter gene assay
Inhibition of STAT3 transcriptional activity in human HaCaT cells after 6 hrs by luciferase reporter gene assay
[PMID: 24920381]
LNCaP IC50
3.4 μM
Compound: 12
Antiproliferative activity against human LNCAP cells after 72 hrs by MTT assay
Antiproliferative activity against human LNCAP cells after 72 hrs by MTT assay
[PMID: 19249204]
LNCaP IC50
> 50 μM
Compound: 5
Cytotoxicity against human LNCAP cells assessed as cell viability after 24 hrs by MTT assay
Cytotoxicity against human LNCAP cells assessed as cell viability after 24 hrs by MTT assay
[PMID: 24920381]
MCF-10A IC50
> 50 μM
Compound: 12
Antiproliferative activity against human MCF10A cells after 72 hrs by MTT assay
Antiproliferative activity against human MCF10A cells after 72 hrs by MTT assay
[PMID: 19249204]
MCF7 IC50
4.19 μM
Compound: 12
Antiproliferative activity against human MCF7 cells after 72 hrs by MTS-PMS assay
Antiproliferative activity against human MCF7 cells after 72 hrs by MTS-PMS assay
[PMID: 19019687]
MCF7 IC50
5.9 μM
Compound: 12
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
[PMID: 19249204]
MDA-MB-231 IC50
6.6 μM
Compound: 12
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
[PMID: 19249204]
PBMC IC50
> 50 μM
Compound: 5
Cytotoxicity against human PBMCs assessed as cell viability after 24 hrs by MTT assay
Cytotoxicity against human PBMCs assessed as cell viability after 24 hrs by MTT assay
[PMID: 24920381]
PC-3 IC50
5.6 μM
Compound: 12
Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay
Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay
[PMID: 19249204]
SK-BR-3 IC50
0.258 μM
Compound: 12
Antiproliferative activity against human SKBR3 cells after 72 hrs by MTS-PMS assay
Antiproliferative activity against human SKBR3 cells after 72 hrs by MTS-PMS assay
[PMID: 19019687]
Molecular Weight

364.39

Formula

C21H20N2O4
CAS No.
SMILES

OC1=CC=C(/C=C/C2=NNC(/C=C/C3=CC=C(O)C(OC)=C3)=C2)C=C1OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Hydrazinocurcumin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hydrazinocurcumin131068-23-0Curcumin pyrazoleOthersendothelial cell proliferationVEGF/VEGFR2metastatic cancerInhibitorinhibitorinhibit

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