131068-23-0
Chemical Structure
Hydrazinocurcumin
Synonym(s): Curcumin pyrazole
- CAS No.: 131068-23-0
- Formula:C21H20N2O4
- Molecular Weight:364.39
IUPAC Name: 4,4'-((1E,1'E)-(1H-pyrazole-3,5-diyl)bis(ethene-2,1-diyl))bis(2-methoxyphenol)
InChIKey: LKLASFRCXLTNMY-FCXRPNKRSA-N
SMILES: OC1=CC=C(/C=C/C2=NNC(/C=C/C3=CC=C(O)C(OC)=C3)=C2)C=C1OC
Biological Activity: Hydrazinocurcumin (Curcumin pyrazole) is a potent endothelial cell proliferation inhibitor (IC50=520 nM). Hydrazinocurcumin disrupts angiogenic signaling pathways and inhibits endothelial cell migration and tube formation, exerting anti-angiogenic activity. Hydrazinocurcumin is promising for research of tumor angiogenesis inhibition, metastatic cancer, and vascular-dependent diseases such as retinopathies[1].
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Hydrazinocurcumin | Hydrazinocurcumin (Curcumin pyrazole) is a potent endothelial cell proliferation inhibitor (IC50=520 nM). Hydrazinocurcumin disrupts angiogenic signaling pathways and inhibits endothelial cell migration and tube formation, exerting anti-angiogenic activity. Hydrazinocurcumin is promising for research of tumor angiogenesis inhibition, metastatic cancer, and vascular-dependent diseases such as retinopathies. | |||||||||||||||||||||
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