2. Academic Validation
  3. Rapid synthesis of triazine inhibitors of inosine monophosphate dehydrogenase

Rapid synthesis of triazine inhibitors of inosine monophosphate dehydrogenase

  • Bioorg Med Chem Lett. 2002 Aug 19;12(16):2137-40. doi: 10.1016/s0960-894x(02)00351-7.
William J Pitts 1,  Junqing Guo,  T G Murali Dhar,  Zhongqi Shen,  Henry H Gu,  Scott H Watterson,  Mark S Bednarz,  Bang Chi Chen,  Joel C Barrish,  Donna Bassolino,  Daniel Cheney,  Catherine A Fleener,  Katherine A Rouleau,  Diane L Hollenbaugh,  Edwin J Iwanowicz
Affiliations

Affiliation

  • 1 Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543-4000, USA. [email protected]
PMID: 12127522 DOI: 10.1016/s0960-894x(02)00351-7
Abstract

A series of novel triazine-based small molecule inhibitors (IV) of inosine monophosphate dehydrogenase was prepared. The synthesis and the structure-activity relationships (SAR) derived from in vitro studies are described.

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