2. Academic Validation
  3. Synthesis and cytotoxic activity of pyridazino[1',6':1,2]pyrido[3,4-b]indol-5-inium derivatives as anti-cancer agents

Synthesis and cytotoxic activity of pyridazino[1',6':1,2]pyrido[3,4-b]indol-5-inium derivatives as anti-cancer agents

  • Bioorg Med Chem Lett. 2002 Sep 16;12(18):2611-4. doi: 10.1016/s0960-894x(02)00472-9.
Alberto Fontana 1,  Enrique J Benito,  M Justina Martín,  Nuria Sánchez,  Ramón Alajarín,  J José Vaquero,  Julio Alvarez-Builla,  Stéphanie Lambel-Giraudet,  Stéphane Leonce,  Alain Pierré,  Daniel Caignard
Affiliations

Affiliation

  • 1 Departamento de Qui;mica Orgánica, Universidad de Alcalá, 28871-Alcalá de Henares, Madrid, Spain.
PMID: 12182872 DOI: 10.1016/s0960-894x(02)00472-9
Abstract

Several new pyridazino[1',6':1,2]pyrido[3,4-b]indol-5-inium derivatives were synthesised from beta-carboline derivatives and their cytotoxic activity and effect on the cell cycle were evaluated against L1210 Cancer cells.

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