2. Academic Validation
  3. Synthesis and anticancer evaluation of vitamin K(3) analogues

Synthesis and anticancer evaluation of vitamin K(3) analogues

  • Bioorg Med Chem Lett. 2002 Oct 7;12(19):2729-32. doi: 10.1016/s0960-894x(02)00532-2.
Chinpiao Chen 1,  Yi-Zhong Liu,  Kak-Shan Shia,  Huan-Yi Tseng
Affiliations

Affiliation

  • 1 Department of Chemistry, National Dong Hwa University, Shoufeng, Hualien, Taiwan, ROC. [email protected]
PMID: 12217364 DOI: 10.1016/s0960-894x(02)00532-2
Abstract

Novel vitamin K(3) analogues were synthesized and evaluated for their Anticancer activity. Compound 6, 9, 10, 11, 14, and (+/-)15 demonstrated a strong inhibitory activity against the tumor cells of A-549, Hep G2, MCF7, MES-SA, MES-SA/Dx5, MKN45, SW-480, and TW-039. Compound (+/-)15 displayed potent tumor cell cytotoxicity, and compound 14 selectively affected MCF7, even though it did not influence normal cells Detroit551 and WI-38. Compound (+/-)15 inhibited MES-SA and MES-SA/Dx5, and this specific result shows that compound (+/-)15 may become a good Anticancer drug candidate.

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