2. Academic Validation
  3. Novel amide-based inhibitors of inosine 5'-monophosphate dehydrogenase

Novel amide-based inhibitors of inosine 5'-monophosphate dehydrogenase

  • Bioorg Med Chem Lett. 2002 Oct 21;12(20):2879-82. doi: 10.1016/s0960-894x(02)00601-7.
Scott H Watterson 1,  Chunjian Liu,  T G Murali Dhar,  Henry H Gu,  William J Pitts,  Joel C Barrish,  Catherine A Fleener,  Katherine Rouleau,  N Z Sherbina,  Diane L Hollenbaugh,  Edwin J Iwanowicz
Affiliations

Affiliation

  • 1 Bristol-Myers Squibb PRI, PO Box 4000, Princeton, NJ 08543-4000, USA. [email protected]
PMID: 12270168 DOI: 10.1016/s0960-894x(02)00601-7
Abstract

A series of novel amide-based small molecule inhibitors of inosine monophosphate dehydrogenase (IMPDH) was explored. The synthesis and the structure-activity relationships (SARs) derived from in vitro studies are described.

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