2. Academic Validation
  3. Novel guanidine-based inhibitors of inosine monophosphate dehydrogenase

Novel guanidine-based inhibitors of inosine monophosphate dehydrogenase

  • Bioorg Med Chem Lett. 2002 Oct 21;12(20):2931-4. doi: 10.1016/s0960-894x(02)00600-5.
Edwin J Iwanowicz 1,  Scott H Watterson,  Chunjian Liu,  Henry H Gu,  Toomas Mitt,  Katerina Leftheris,  Joel C Barrish,  Catherine A Fleener,  Katherine Rouleau,  N Z Sherbina,  Diane L Hollenbaugh
Affiliations

Affiliation

  • 1 Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543-4000, USA. [email protected]
PMID: 12270177 DOI: 10.1016/s0960-894x(02)00600-5
Abstract

A series of novel guanidine-based small molecule inhibitors of inosine monophosphate dehydrogenase (IMPDH) was explored. IMPDH catalyzes the rate determining step in guanine nucleotide biosynthesis and is a target for Anticancer, immunosuppressive and Antiviral therapy. The synthesis and the structure-activity relationships (SARs), derived from in vitro studies, for this new series of inhibitors is given.

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