2. Academic Validation
  3. Synthesis and structure-activity relationships of aminoalkylazetidines as ORL1 receptor ligands

Synthesis and structure-activity relationships of aminoalkylazetidines as ORL1 receptor ligands

  • Bioorg Med Chem Lett. 2002 Nov 4;12(21):3157-60. doi: 10.1016/s0960-894x(02)00652-2.
Wen-Lian Wu 1,  Mary Ann Caplen,  Martin S Domalski,  Hongtao Zhang,  Ahmad Fawzi,  Duane A Burnett
Affiliations

Affiliation

  • 1 Schering Plough Research Institute, 2015 Galloping Hill Road, MS 2800, Kenilworth, NJ 07033-0539, USA.
PMID: 12372523 DOI: 10.1016/s0960-894x(02)00652-2
Abstract

A series of aminoalkylazetidines has been discovered as novel ORL1 receptor ligands. Structure-activity relationships have been investigated at the azetidine N and the alkyl side chain sites. Several potent and selective analogues have been identified.

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