2. Academic Validation
  3. Benzotrithiole 2-oxide: a new family of thiol-activated DNA-cleaving functionalities

Benzotrithiole 2-oxide: a new family of thiol-activated DNA-cleaving functionalities

  • Bioorg Med Chem Lett. 2002 Nov 18;12(22):3259-61. doi: 10.1016/s0960-894x(02)00721-7.
Alex H F Lee 1,  Albert S C Chan,  Tianhu Li
Affiliations

Affiliation

  • 1 Open Laboratory of Chirotechnology of the Institute of Molecular Technology for Drug Discovery and Synthesis and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong
PMID: 12392727 DOI: 10.1016/s0960-894x(02)00721-7
Abstract

It was demonstrated in our studies that benzotrithiole 2-oxide was capable of causing efficient DNA cleavage in the presence of 2-mercaptoethanol or glutathione and exhibited potent cytotoxic properties against certain Cancer cell lines.

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