2. Academic Validation
  3. The TosMIC approach to 3-(oxazol-5-yl) indoles: application to the synthesis of indole-based IMPDH inhibitors

The TosMIC approach to 3-(oxazol-5-yl) indoles: application to the synthesis of indole-based IMPDH inhibitors

  • Bioorg Med Chem Lett. 2002 Nov 18;12(22):3305-8. doi: 10.1016/s0960-894x(02)00748-5.
T G Murali Dhar 1,  Zhongqi Shen,  Catherine A Fleener,  Katherine A Rouleau,  Joel C Barrish,  Diane L Hollenbaugh,  Edwin J Iwanowicz
Affiliations

Affiliation

  • 1 Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543-4000, USA. [email protected]
PMID: 12392738 DOI: 10.1016/s0960-894x(02)00748-5
Abstract

A modified approach to the synthesis of 3-(oxazolyl-5-yl) indoles is reported. This method was applied to the synthesis of series of novel indole based inhibitors of inosine monophosphate dehydrogenase (IMPDH). The synthesis and the structure-activity relationships (SARs), derived from in vitro studies, for this new series of inhibitors is given.

Figures