2. Academic Validation
  3. Prodrugs of 4'-demethyl-4-deoxypodophyllotoxin: synthesis and evaluation of the antitumor activity

Prodrugs of 4'-demethyl-4-deoxypodophyllotoxin: synthesis and evaluation of the antitumor activity

  • Bioorg Med Chem Lett. 2002 Dec 2;12(23):3435-8. doi: 10.1016/s0960-894x(02)00758-8.
Yong Kim 1,  Young-Jae You,  Nguyen Hai Nam,  Byung-Zun Ahn
Affiliations

Affiliation

  • 1 College of Pharmacy, Chungnam National University, Taejon, South Korea.
PMID: 12419378 DOI: 10.1016/s0960-894x(02)00758-8
Abstract

A series of prodrugs of 4'-demethyl-4-deoxypodophyllotoxin (DDPT) including carbamates (3-8), a carbonate (9) and water-soluble Amino Acid Derivatives (10-17) were prepared and tested for their antitumor activity. The carbamate 6 (2-hydroxyethylcarbamoyl-DDPT), carbonate 9 (2-chloroethyloxycarbonyl-DDPT), and most of amino acid prodrugs (12-17) showed enhanced antitumor activity.

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