2. Academic Validation
  3. A new strategy for neurochemical photodelivery: metal-ligand heterolytic cleavage

A new strategy for neurochemical photodelivery: metal-ligand heterolytic cleavage

  • J Am Chem Soc. 2003 Jan 29;125(4):882-3. doi: 10.1021/ja0278943.
Leonardo Zayat 1,  Cecilia Calero,  Pablo Alborés,  Luis Baraldo,  Roberto Etchenique
Affiliations

Affiliation

  • 1 Departamento de Química Inorgánica, INQUIMAE, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellón 2, AR1428EHA Buenos Aires, Argentina.
PMID: 12537482 DOI: 10.1021/ja0278943
Abstract

A new strategy to build caged-compounds is presented. The approach is based on heterolytic photocleavage of a metal-ligand bond in a coordination compound. A ruthenium polypyridine complex, containing the neurocompound 4-amino pyridine (4AP) is used as the core of the phototrigger. The biomolecule is released by irradiation with visible LIGHT (>480 nm). The liberated 4AP promotes the activation of a leech neuron by means of blocking its K+ channels. The syntesis, characterization, and the inherent advantages of this method are discussed.

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