2. Academic Validation
  3. Novel inhibitors of IMPDH: a highly potent and selective quinolone-based series

Novel inhibitors of IMPDH: a highly potent and selective quinolone-based series

  • Bioorg Med Chem Lett. 2003 Feb 10;13(3):543-6. doi: 10.1016/s0960-894x(02)00944-7.
Scott H Watterson 1,  Marianne Carlsen,  T G Murali Dhar,  Zhongqi Shen,  William J Pitts,  Junqing Guo,  Henry H Gu,  Derek Norris,  John Chorba,  Ping Chen,  Daniel Cheney,  Mark Witmer,  Catherine A Fleener,  Katherine Rouleau,  Robert Townsend,  Diane L Hollenbaugh,  Edwin J Iwanowicz
Affiliations

Affiliation

  • 1 Bristol-Myers Squibb PRI, PO Box 400, Princeton, NJ 08543-4000, USA. [email protected]
PMID: 12565968 DOI: 10.1016/s0960-894x(02)00944-7
Abstract

A series of novel quinolone-based small molecule inhibitors of inosine monophosphate dehydrogenase (IMPDH) was explored. The synthesis and the structure-activity relationships (SARs) derived from in vitro studies are described.

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