2. Academic Validation
  3. New oplopane and eremophilane derivatives from Robinsonecio gerberifolius

New oplopane and eremophilane derivatives from Robinsonecio gerberifolius

  • J Nat Prod. 2003 Feb;66(2):225-9. doi: 10.1021/np0203739.
Amira Arciniegas 1,  Ana-L Pérez-Castorena,  Sibet Reyes,  José Luis Contreras,  Alfonso Romo De Vivar
Affiliations

Affiliation

  • 1 Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán 04510, D.F., México.
PMID: 12608854 DOI: 10.1021/np0203739
Abstract

A phytochemical study of Robinsonecio gerberifolius afforded six new sesquiterpenoids, two oplopane (1and 2) and four eremophilane derivatives (3-6). The structures of these compounds were elucidated on spectroscopic grounds, and the absolute configurations of compounds 3 and 4 were established from CD analysis. The known 3beta-angeloyloxy-1,10-epoxyfuranoeremophilane (7) was also isolated, and its stereochemistry was revised. The cytotoxic activities of compounds 1-7 were determined against five human Cancer cell lines.

Figures