2. Academic Validation
  3. A novel constituent from Rollinia mucosa, rollicosin, and a new approach to develop annonaceous acetogenins as potential antitumor agents

A novel constituent from Rollinia mucosa, rollicosin, and a new approach to develop annonaceous acetogenins as potential antitumor agents

  • J Nat Prod. 2003 Feb;66(2):279-81. doi: 10.1021/np020236b.
Chih-Chuang Liaw 1,  Fang-Rong Chang,  Ming-Jung Wu,  Yang-Chang Wu
Affiliations

Affiliation

  • 1 Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China.
PMID: 12608866 DOI: 10.1021/np020236b
Abstract

Rollicosin (1), a new Annonaceous acetogenin, was isolated from the unripe fruits of Rollinia mucosa. Rollicosin (1) is the first compound of this type to contain lactone moieties on both sides of the aliphatic chain and to lack either tetrahydrofuran or tetrahydropyran rings. Its structure was determined on the basis of spectroscopic analyses. This compound may serve as a new prototype molecule to develop Annonaceous acetogenins as potential antitumor agents.

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