2. Academic Validation
  3. Synthesis and anticancer effect of chrysin derivatives

Synthesis and anticancer effect of chrysin derivatives

  • Bioorg Med Chem Lett. 2003 Mar 10;13(5):881-4. doi: 10.1016/s0960-894x(02)01081-8.
Xing Zheng 1,  Wei-Dong Meng,  Yang-Yan Xu,  Jian-Guo Cao,  Feng-Ling Qing
Affiliations

Affiliation

  • 1 College of Chemistry and Chemical Engineering, Donghua Unversity, 1882 West Yanan Lu, Shanghai 200051, PR, China.
PMID: 12617913 DOI: 10.1016/s0960-894x(02)01081-8
Abstract

A series of chrysin derivatives, prepared by alkylation, halogenation, nitration, methylation, acetylation and trifluoromethylation, were tested in vitro against human gastric adenocarcinoma cell line (SGC-7901) and colorectal adenocarcinoma (HT-29) cells. Among these derivatives of chrysin, 5,7-dimethoxy-8-iodochrysin 3 and 8-bromo-5-hydroxy-7-methoxychrysin 11 have the strongest activities against SGC-7901 and HT-29 cells, respectively. 5,7-Dihydroxy-8-nitrochrysin 12 were found to have strong activities against both SGC-7901 and HT-29 cells.

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