2. Academic Validation
  3. Cancer chemotherapy: a SN-38 (7-ethyl-10-hydroxycamptothecin) glucuronide prodrug for treatment by a PMT (Prodrug MonoTherapy) strategy

Cancer chemotherapy: a SN-38 (7-ethyl-10-hydroxycamptothecin) glucuronide prodrug for treatment by a PMT (Prodrug MonoTherapy) strategy

  • Bioorg Med Chem Lett. 2003 Mar 10;13(5):947-50. doi: 10.1016/s0960-894x(02)01080-6.
Stéphane Angenault 1,  Sylvie Thirot,  Frédéric Schmidt,  Claude Monneret,  Bruno Pfeiffer,  Pierre Renard
Affiliations

Affiliation

  • 1 UMR176 CNRS/Institut Curie, 26, rue d'Ulm, 75248 Paris Cedex 05, France.
PMID: 12617927 DOI: 10.1016/s0960-894x(02)01080-6
Abstract

A glucuronide-based prodrug of SN-38 (7-ethyl-10-hydroxycamptothecin) has been synthesized for use in a Prodrug MonoTherapy Strategy (PMT). Since this prodrug is significantly less cytotoxic than SN-38 itself and efficiently releases the drug in vitro in the presence of beta-D-glucuronidase, it can be considered as an appropriate candidate for Cancer treatment by a PMT strategy.

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