2. Academic Validation
  3. Antimycobacterial pimarane diterpenes from the Fungus Diaporthe sp

Antimycobacterial pimarane diterpenes from the Fungus Diaporthe sp

  • Bioorg Med Chem Lett. 2003 Apr 7;13(7):1253-5. doi: 10.1016/s0960-894x(03)00111-2.
Suppamit Dettrakul 1,  Prasat Kittakoop,  Masahiko Isaka,  Sombat Nopichai,  Chotika Suyarnsestakorn,  Morakot Tanticharoen,  Yodhathai Thebtaranonth
Affiliations

Affiliation

  • 1 Department of Chemistry, Faculty of Science, Mahidol University, Bangkok, Thailand.
PMID: 12657257 DOI: 10.1016/s0960-894x(03)00111-2
Abstract

Two new pimarane diterpenes, diaportheins A (1) and B (2), were isolated from a culture broth of the fungus Diaporthe sp. BCC 6140. Diaporthein B (2) strongly inhibited the growth of Mycobacterium tuberculosis with the MIC value of 3.1 microg/mL, while diaporthein A (1) showed only mild activity (MIC value of 200 microg/mL).

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