2. Academic Validation
  3. Human herpesvirus 6 variant A glycoprotein H-glycoprotein L-glycoprotein Q complex associates with human CD46

Human herpesvirus 6 variant A glycoprotein H-glycoprotein L-glycoprotein Q complex associates with human CD46

  • J Virol. 2003 Apr;77(8):4992-9. doi: 10.1128/jvi.77.8.4992-4999.2003.
Yasuko Mori 1,  Xuwei Yang,  Pilailuk Akkapaiboon,  Toshiomi Okuno,  Koichi Yamanishi
Affiliations

Affiliation

  • 1 Department of Microbiology, Osaka University Medical School, Suita, Osaka 565-0871, USA. [email protected]
PMID: 12663806 DOI: 10.1128/jvi.77.8.4992-4999.2003
Abstract

Human CD46 is a cellular receptor for human herpesvirus 6 (HHV-6). Virus entry into host cells requires a glycoprotein H (gH)-glycoprotein L (gL) complex. We show that the CD46 ectodomain blocked HHV-6 Infection and bound a complex of gH-gL and the 80-kDa U100 gene product, designated glycoprotein Q, indicating that the complex is a viral ligand for CD46.

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